Spatial tumor-immune modeling.
de Pillis, L.G., Mallet, D.G., Radunskaya, A.E. (2006)
Computational & Mathematical Methods in Medicine
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de Pillis, L.G., Mallet, D.G., Radunskaya, A.E. (2006)
Computational & Mathematical Methods in Medicine
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Kolobov, A.V., Polezhaev, A.A., Solyanik, G.I. (2000)
Journal of Theoretical Medicine
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H. Enderling, D. Park, L. Hlatky, P. Hahnfeldt (2009)
Mathematical Modelling of Natural Phenomena
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Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpopulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited...