Displaying similar documents to “Influence of time delays on the Hahnfeldt et al. angiogenesis model dynamics”

Immunotherapy with interleukin-2: A study based on mathematical modeling

Sandip Banerjee (2008)

International Journal of Applied Mathematics and Computer Science

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The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.

Dynamics of the tumor-immune system competition - the effect of time delay

Magda Galach (2003)

International Journal of Applied Mathematics and Computer Science

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The model analyzed in this paper is based on the model set forth by V.A. Kuznetsov and M.A. Taylor, which describes a competition between the tumor and immune cells. Kuznetsov and Taylor assumed that tumor-immune interactions can be described by a Michaelis-Menten function. In the present paper a simplified version of the Kuznetsov-Taylor model (where immune reactions are described by a bilinear term) is studied. On the other hand, the effect of time delay is taken into account in order...

Model of AIDS-related tumour with time delay

Marek Bodnar, Urszula Foryś, Zuzanna Szymańska (2009)

Applicationes Mathematicae

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We present and compare two simple models of immune system and cancer cell interactions. The first model reflects simple cancer disease progression and serves as our "control" case. The second describes the progression of a cancer disease in the case of a patient infected with the HIV-1 virus.

Angiogenesis process with vessel impairment for Gompertzian and logistic type of tumour growth

Jan Poleszczuk, Urszula Foryś (2009)

Applicationes Mathematicae

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We propose two models of vessel impairment in the process of tumour angiogenesis and we consider three types of treatment: standard chemotherapy, antiangiogenic treatment and a combined treatment. The models are based on the idea of Hahnfeldt et al. that the carrying capacity for any solid tumour depends on its vessel density. In the models proposed the carrying capacity also depends on the process of vessel impairment. In the first model a logistic type equation is used to describe...

Coupled analytical and numerical approach to uncovering new regulatory mechanisms of intracellular processes

Jarosław Śmieja (2010)

International Journal of Applied Mathematics and Computer Science

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The paper deals with the analysis of signaling pathways aimed at uncovering new regulatory processes regulating cell responses. First, general issues of comparing simulation and experimental data are discussed, and various aspects of data normalization are covered. Then, a model of a particular signaling pathway, induced by Interferon-β, is briefly introduced. It serves as an example illustrating how mathematical modeling can be used for inferring the structure of a regulatory system...

A mathematical model of HIV-1 infection including the saturation effect of healthy cell proliferation

Mahiéddine Kouche, Bedr'eddine Ainseba (2010)

International Journal of Applied Mathematics and Computer Science

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In this paper we derive a model describing the dynamics of HIV-1 infection in tissue culture where the infection spreads directly from infected cells to healthy cells trough cell-to-cell contact. We assume that the infection rate between healthy and infected cells is a saturating function of cell concentration. Our analysis shows that if the basic reproduction number does not exceed unity then infected cells are cleared and the disease dies out. Otherwise, the infection is persistent...

Time delays in proliferation and apoptosis for solid avascular tumour

Urszula Foryś, Mikhail Kolev (2003)

Banach Center Publications

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The role of time delays in solid avascular tumour growth is considered. The model is formulated in terms of a reaction-diffusion equation and mass conservation law. Two main processes are taken into account-proliferation and apoptosis. We introduce time delay first in underlying apoptosis only and then in both processes. In the absence of necrosis the model reduces to one ordinary differential equation with one discrete delay which describes the changes of tumour radius. Basic properties...

New Computational Tools for Modeling Chronic Myelogenous Leukemia

M. M. Peet, P. S. Kim, S.-I. Niculescu, D. Levy (2009)

Mathematical Modelling of Natural Phenomena

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In this paper, we consider a system of nonlinear delay-differential equations (DDEs) which models the dynamics of the interaction between chronic myelogenous leukemia (CML), imatinib, and the anti-leukemia immune response. Because of the chaotic nature of the dynamics and the sparse nature of experimental data, we look for ways to use computation to analyze the model without employing direct numerical simulation. In particular, we develop several tools using Lyapunov-Krasovskii analysis...