The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts

A. Szabó; A. Czirók

Mathematical Modelling of Natural Phenomena (2010)

  • Volume: 5, Issue: 1, page 106-122
  • ISSN: 0973-5348

Abstract

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Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy between surface tension and cell-cell adhesion, we demonstrate that such a mechanism is unable to recruit cells to the sprout. Moreover, the expansion of such hypothetical sprouts is limited by a form of the Plateau-Taylor instability. In contrast, actively moving cells – guided by cell-cell contacts – can readily populate and expand linear sprouts. We argue that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation.

How to cite

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Szabó, A., and Czirók, A.. "The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts." Mathematical Modelling of Natural Phenomena 5.1 (2010): 106-122. <http://eudml.org/doc/197659>.

@article{Szabó2010,
abstract = {Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy between surface tension and cell-cell adhesion, we demonstrate that such a mechanism is unable to recruit cells to the sprout. Moreover, the expansion of such hypothetical sprouts is limited by a form of the Plateau-Taylor instability. In contrast, actively moving cells – guided by cell-cell contacts – can readily populate and expand linear sprouts. We argue that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation.},
author = {Szabó, A., Czirók, A.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {sprouting; leader cell; Potts model},
language = {eng},
month = {2},
number = {1},
pages = {106-122},
publisher = {EDP Sciences},
title = {The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts},
url = {http://eudml.org/doc/197659},
volume = {5},
year = {2010},
}

TY - JOUR
AU - Szabó, A.
AU - Czirók, A.
TI - The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts
JO - Mathematical Modelling of Natural Phenomena
DA - 2010/2//
PB - EDP Sciences
VL - 5
IS - 1
SP - 106
EP - 122
AB - Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy between surface tension and cell-cell adhesion, we demonstrate that such a mechanism is unable to recruit cells to the sprout. Moreover, the expansion of such hypothetical sprouts is limited by a form of the Plateau-Taylor instability. In contrast, actively moving cells – guided by cell-cell contacts – can readily populate and expand linear sprouts. We argue that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation.
LA - eng
KW - sprouting; leader cell; Potts model
UR - http://eudml.org/doc/197659
ER -

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