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The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts

A. SzabóA. Czirók — 2010

Mathematical Modelling of Natural Phenomena

Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy...

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