Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting

E. M. C. D’Agata; G. F. Webb; J. Pressley

Mathematical Modelling of Natural Phenomena (2010)

  • Volume: 5, Issue: 3, page 76-93
  • ISSN: 0973-5348

Abstract

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Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential for exchange of genetic information.Methods: A deterministic mathematical model was developed to characterize the transmission dynamics of HA-MRSA and CA-MRSA in the hospital setting and to quantify the emergence of co-colonization with both strainsResults: The model analysis shows that the state of co-colonization becomes endemic over time and that typically there is no competitive exclusion of either strain. Increasing the length of stay or rate of hospital entry among patients colonized with CA-MRSA leads to a rapid increase in the co-colonized state. Compared to MRSA decolonization strategy, improving hand hygiene compliance has the greatest impact on decreasing the prevalence of HA-MRSA, CA-MRSA and the co-colonized state.Conclusions: The model predicts that with the expanding community reservoir of CA-MRSA, the majority of hospitalized patients will become colonized with both CA-MRSA and HA-MRSA.

How to cite

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D’Agata, E. M. C., Webb, G. F., and Pressley, J.. "Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting." Mathematical Modelling of Natural Phenomena 5.3 (2010): 76-93. <http://eudml.org/doc/197712>.

@article{D2010,
abstract = {Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential for exchange of genetic information.Methods: A deterministic mathematical model was developed to characterize the transmission dynamics of HA-MRSA and CA-MRSA in the hospital setting and to quantify the emergence of co-colonization with both strainsResults: The model analysis shows that the state of co-colonization becomes endemic over time and that typically there is no competitive exclusion of either strain. Increasing the length of stay or rate of hospital entry among patients colonized with CA-MRSA leads to a rapid increase in the co-colonized state. Compared to MRSA decolonization strategy, improving hand hygiene compliance has the greatest impact on decreasing the prevalence of HA-MRSA, CA-MRSA and the co-colonized state.Conclusions: The model predicts that with the expanding community reservoir of CA-MRSA, the majority of hospitalized patients will become colonized with both CA-MRSA and HA-MRSA.},
author = {D’Agata, E. M. C., Webb, G. F., Pressley, J.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {methicillin-resistance; Staphylococcus aureus; community; hospital; co-colonization; staphylococcus aureus; ordinary differential equations},
language = {eng},
month = {4},
number = {3},
pages = {76-93},
publisher = {EDP Sciences},
title = {Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting},
url = {http://eudml.org/doc/197712},
volume = {5},
year = {2010},
}

TY - JOUR
AU - D’Agata, E. M. C.
AU - Webb, G. F.
AU - Pressley, J.
TI - Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting
JO - Mathematical Modelling of Natural Phenomena
DA - 2010/4//
PB - EDP Sciences
VL - 5
IS - 3
SP - 76
EP - 93
AB - Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential for exchange of genetic information.Methods: A deterministic mathematical model was developed to characterize the transmission dynamics of HA-MRSA and CA-MRSA in the hospital setting and to quantify the emergence of co-colonization with both strainsResults: The model analysis shows that the state of co-colonization becomes endemic over time and that typically there is no competitive exclusion of either strain. Increasing the length of stay or rate of hospital entry among patients colonized with CA-MRSA leads to a rapid increase in the co-colonized state. Compared to MRSA decolonization strategy, improving hand hygiene compliance has the greatest impact on decreasing the prevalence of HA-MRSA, CA-MRSA and the co-colonized state.Conclusions: The model predicts that with the expanding community reservoir of CA-MRSA, the majority of hospitalized patients will become colonized with both CA-MRSA and HA-MRSA.
LA - eng
KW - methicillin-resistance; Staphylococcus aureus; community; hospital; co-colonization; staphylococcus aureus; ordinary differential equations
UR - http://eudml.org/doc/197712
ER -

References

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  1. T. Baba, F. Takeuchi, M. Kuroda, H. Yuzawa, K. Aoki, A. Oguchi, Y. Nagai, N. Iwama, K. Asano T. Naimi. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet, 359 (2002), No. 9320, 1819–1827. 
  2. M. Bassetti, E. Nicco, M. Mikulska. Why is community-associated MRSA spreading across the world and how will it change clinical practice?International Journal of Antimicrobial Agents, 34 (2009), No. S1, S15–S19.  
  3. C. Cespedes, B. Saïd-Salim, M. Miller, S. H. Lo, B. N. Kreiswirth, R. J. Gordon, P. Vavagiakis, R. S. Klein F. D. Lowy. The clonality of Staphylococcus aureus nasal carriage. J. Infect. Dis., 191 (2005), 444–452. 
  4. P. G. Coen, M. Wilks, M. Dall’Antonia M. Millar. Detection of multiple-strain carriers: the value of re-sampling. J. Theor. Biol., 240 (2006), No. 1, 98–103. 
  5. B. Crawford C. M. Kribs Zaleta. The impact of vaccination and coinfection on HPV and cervical cancer. Discrete and Continuous Dynamical Systems Series B, 12 (2009), No. 2, 279–304. 
  6. E. M. C. D’Agata, G. F. Webb M. Horn. A mathematical model quantifying the impact of antibiotic exposure and other interventions on the endemic prevalence of vancomycin-resistant Enterococci. J. Infect. Dis., 192 (2005), 2004–2011. 
  7. E. M. C. D’Agata, G. F. Webb, M. A. Horn, R. C. Moellering S. Ruan. Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. Clin. Infect. Dis., 48 (2009), No. 3, 274–284. 
  8. S. L. Davis, M. J. Rybak, M. Amjad, G. W. Kaatz P. S. McKinnon. Characteristics of patients with healthcare-associated infection due of SCCmec Type IV methcillin-resistant Staphylococcus aureus. Infect. Control Hosp. Epidemiol., 27 (2006), 1025–1031. 
  9. D. J. Diekema M. Climo. Preventing MRSA infections: finding it is not enough. JAMA, 299 (2008), No. 10, 1190–1192. 
  10. B. A. Diep, H. F. Chambers, C. J. Graber, J. D. Szumowski, L. G. Miller, L. L. Han, J. H. Chen, F. Lin, J. Lin, T. H. Phan, H. A. Carleton, L. K. McDougal, F. C. Tenover, D. E. Cohen, K. H. Mayer, G. F. Sensabaugh F. Perdreau-Remington. Emergence of multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann. Intern. Med., 148 (2008), No. 4, 249–257. 
  11. B. C. Herold, L. C. Immergluck, L. C. Maranan, D. Lauderdale, R. Gaskin, S. Boyle-Vavra, C. D. Leitch R. S. Daum. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA, 279 (1998), No. 8, 593–508. 
  12. A. I. Hidron, E. V. Kourbatova, J. S. Halvosa, B. J. Terrell, L. K. McDougal, H. M. Tenover M. D. King. Risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin. Infect. Dis., 15 (2005), 159–166. 
  13. W. R. Jarvis, J. Schlosser, R. Y. Chinn, S. Tweeten M. Jackson. National prevalence of methicillin-resistant Staphylococcus aureus in inpatients at US health care facilities. Am. J. Infect. Control, 35 (2007), No. 10, 631–637. 
  14. E. Kajita, J. T. Okano, E. N. Bodine, S. P. Layne S. Blower. Modelling an outbreak of an emerging pathogen. Nat. Rev. Microbiol., 5 (2007), 700–709. 
  15. R. M. Klevens, M. A. Morrison, J. Nadle, S. Petit, K. Gershman, S. Ray, M. Harrison, R. Lynfield, G. Dumyati, J. M. Townes, A. S. Craig, E. R. Zell, G. E. Fosheim, L. K. McDougal, R. B. Carey S. K. Fridkin. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA, 298 (2007), 1763–1771. 
  16. E. Lautenbach, P. Tolomeo, N. Black J. Maslow. Risk factors for fecal colonization with multiple distinct strains of Escherichia coli among long-term care facility residents. Infect. Control Hosp. Epidemiol., 30 (2009), 491–493. 
  17. J. Li, M. Zhien, S. P. Blythe C. Castillo-Chavez. Coexistence of pathogens in sexually-transmitted disease models. J. Math. Biol., 47 (2003), No. 6, 547–568. 
  18. E. S. McBryde, A. N. Pettitt D. L. S. McElwain. A stochastic mathematical model of methicillin resistant Staphylococcus aureus transmission in an intensive care unit: predicting the impact of interventions. J. Theor. Biol., 245 (2007), No. 3, 470–481. 
  19. L. G. Miller, F. Perdreau-Remington, G. Rieg, S. Mehdi, J. Perlroth, A. S. Bayer, A. W. Tang, T. O. Phung B. Spellberg. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. New Engl. J. Med., 352 (2005), No. 14, 1445–1453. 
  20. K. Okuma, K. Iwakawa, J. D. Turnidge, W. B. Grubb, J. M. Bell, F. G. O’Brien, G. W. Coombs, J. W. Pearman, F. C. Tenover, M. Kapi, C. Tiensasitorn, T. Ito K. Hiramatsu. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J. Clin. Microbiol., 40 (2002), No. 11, 4289–4294. 
  21. M. Patel, K. B. Waites, C. J. Hoesley, A. M. Stamm, K. C. Canupp S. A. MoserEmergence of USA 300 MRSA in a tertiary medical centre: implications for epidemiological studies. J. Hosp. Infect., 68 (2008), No. 3, 208–213. 
  22. K. J. Popovich, R. A. Weinstein, B. Hota. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin. Infect. Dis., 46 (2008), 787–794.  
  23. J. Pressley, E. M. C. D’Agata, G. F. Webb. The effect of co-colonization with community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus strains on competitive exclusion. J. Theor. Biol., (2010), to appear.  
  24. U. Seybold, E. V. Kourbatova, J. G. Johnson, S. J. Halvosa, Y. F. Wang, M. D. King, S. M. Ray H. M. Blumberg. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA 300 genotype as a major cause of health care-associated blood stream infections. Clin. Infect. Dis., 42 (2006), 647–666. 
  25. A. Tristan, M. Bes, H. Meugnier, G. Lina, B. Bozdogan, P. Courvalin, M. Reverdy, M. Enright, F. Vandenesch J. Etienne. Global distribution of Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus. Emerg. Infect. Dis., 13 (2007), No. 4, 594–600. 
  26. H. F. Wertheim, J. Verveer, H. A. Boelens, van A. Belkum, H. A. Verbrugh M. C. Vos. Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults. Antimicrob. Agents Chemother., 49 (2005), No. 4, 1465–1467. 
  27. M. Xiridou, B. Borkent-Raven, J. Hulshof J. Wallinga. How hepatitis D virus can hinder the control of hepatitis B virus. PLoS ONE, 4 (2009), 4. 

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