The Effects of HIV-1 Infection on Latent Tuberculosis

Bauer, Amy L., et al. "The Effects of HIV-1 Infection on Latent Tuberculosis." Mathematical Modelling of Natural Phenomena 3.7 (2008): 229-266. <http://eudml.org/doc/222415>.

@article{Bauer2008,
abstract = { Tuberculosis is the leading cause of death due to infectious diseases in the world today, and it is increasing due to co-infection with HIV-1, the causative agent of AIDS. Here, we examine the impact that HIV-1 infection has on persons with latent tuberculosis. Based on previous work, we develop a mathematical model of an adaptive immune response in the lung which considers relevant immune effectors such as macrophages, various sub-populations of T-cells, and key cytokines to predict which mechanisms are important to HIV-1 infection induced reactivation of tuberculosis. Our results indicate that persons latently infected with TB who are subsequently co-infected with HIV-1 will suffer reactive TB. The mechanisms that contribute to this are essentially related to a completely different cytokine environment at the onset of HIV-1 infection due to the presence of Mycobacterium tuberculosis. Our analysis suggests that macrophages play an important role during co-infection and decreases in macrophage counts are coupled to a decline in CD4+ T-cells and increased viral loads. These mechanisms are also coupled to lower recruitment of T-cells and macrophages, compromising protective immunity in the lung and eventually leading to TB reactivation. These results point to potential targets for drug and vaccine therapies. },
author = {Bauer, Amy L., Hogue, Ian B., Marino, Simeone, Kirschner, Denise E.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {HIV; Mycobacterium tuberculosis; macrophages; uncertainty analysis; sensitivity analysis; mathematical model; immunology; Mycobacterium tuberculosis; sensitivity analysis},
language = {eng},
month = {10},
number = {7},
pages = {229-266},
publisher = {EDP Sciences},
title = {The Effects of HIV-1 Infection on Latent Tuberculosis},
url = {http://eudml.org/doc/222415},
volume = {3},
year = {2008},
}

TY - JOUR
AU - Bauer, Amy L.
AU - Hogue, Ian B.
AU - Marino, Simeone
AU - Kirschner, Denise E.
TI - The Effects of HIV-1 Infection on Latent Tuberculosis
JO - Mathematical Modelling of Natural Phenomena
DA - 2008/10//
PB - EDP Sciences
VL - 3
IS - 7
SP - 229
EP - 266
AB - Tuberculosis is the leading cause of death due to infectious diseases in the world today, and it is increasing due to co-infection with HIV-1, the causative agent of AIDS. Here, we examine the impact that HIV-1 infection has on persons with latent tuberculosis. Based on previous work, we develop a mathematical model of an adaptive immune response in the lung which considers relevant immune effectors such as macrophages, various sub-populations of T-cells, and key cytokines to predict which mechanisms are important to HIV-1 infection induced reactivation of tuberculosis. Our results indicate that persons latently infected with TB who are subsequently co-infected with HIV-1 will suffer reactive TB. The mechanisms that contribute to this are essentially related to a completely different cytokine environment at the onset of HIV-1 infection due to the presence of Mycobacterium tuberculosis. Our analysis suggests that macrophages play an important role during co-infection and decreases in macrophage counts are coupled to a decline in CD4+ T-cells and increased viral loads. These mechanisms are also coupled to lower recruitment of T-cells and macrophages, compromising protective immunity in the lung and eventually leading to TB reactivation. These results point to potential targets for drug and vaccine therapies.
LA - eng
KW - HIV; Mycobacterium tuberculosis; macrophages; uncertainty analysis; sensitivity analysis; mathematical model; immunology; Mycobacterium tuberculosis; sensitivity analysis
UR - http://eudml.org/doc/222415
ER -