Application of Hybrid Models to Blood Cell Production in the Bone Marrow

N. Bessonov; F. Crauste; S. Fischer; P. Kurbatova; V. Volpert

Mathematical Modelling of Natural Phenomena (2011)

  • Volume: 6, Issue: 7, page 2-12
  • ISSN: 0973-5348

Abstract

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A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.

How to cite

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Bessonov, N., et al. "Application of Hybrid Models to Blood Cell Production in the Bone Marrow." Mathematical Modelling of Natural Phenomena 6.7 (2011): 2-12. <http://eudml.org/doc/222447>.

@article{Bessonov2011,
abstract = {A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.},
author = {Bessonov, N., Crauste, F., Fischer, S., Kurbatova, P., Volpert, V.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {hybrid models; erythropoiesis; regulatory mechanisms},
language = {eng},
month = {6},
number = {7},
pages = {2-12},
publisher = {EDP Sciences},
title = {Application of Hybrid Models to Blood Cell Production in the Bone Marrow},
url = {http://eudml.org/doc/222447},
volume = {6},
year = {2011},
}

TY - JOUR
AU - Bessonov, N.
AU - Crauste, F.
AU - Fischer, S.
AU - Kurbatova, P.
AU - Volpert, V.
TI - Application of Hybrid Models to Blood Cell Production in the Bone Marrow
JO - Mathematical Modelling of Natural Phenomena
DA - 2011/6//
PB - EDP Sciences
VL - 6
IS - 7
SP - 2
EP - 12
AB - A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
LA - eng
KW - hybrid models; erythropoiesis; regulatory mechanisms
UR - http://eudml.org/doc/222447
ER -

References

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