Displaying similar documents to “Application of Hybrid Models to Blood Cell Production in the Bone Marrow”

Individual Cell-Based Model for In-Vitro Mesothelial Invasion of Ovarian Cancer

C. Giverso, M. Scianna, L. Preziosi, N. Lo Buono, A. Funaro (2010)

Mathematical Modelling of Natural Phenomena

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In vitro transmesothelial migration assays of ovarian cancer cells, isolated or aggregated in multicellular spheroids, are reproduced deducing suitable Cellular Potts Models (CPM). We show that the simulations are in good agreement with the experimental evidence and that the overall process is regulated by the activity of matrix metalloproteinases (MMPs) and by the interplay of the adhesive properties of the cells with the extracellular...

A Maturity-Structured Mathematical Model of Mutation, Acquisition in the Absence of Homeostatic Regulation

S. N. Gentry, R. Ashkenazi, T. L. Jackson (2009)

Mathematical Modelling of Natural Phenomena

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Most mammalian tissues are organized into a hierarchical structure of stem, progenitor, and differentiated cells. Tumors exhibit similar hierarchy, even if it is abnormal in comparison with healthy tissue. In particular, it is believed that a small population of cancer stem cells drives tumorigenesis in certain malignancies. These cancer stem cells are derived from transformed stem cells or mutated progenitors that have acquired stem-cell qualities, specifically the ability to self-renew....

Modeling the Cancer Stem Cell Hypothesis

C. Calmelet, A. Prokop, J. Mensah, L. J. McCawley, P. S. Crooke (2010)

Mathematical Modelling of Natural Phenomena

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Solid tumors and hematological cancers contain small population of tumor cells that are believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukemia, myeloma, breast, prostate, pancreas, colon, brain and lung cancers. It is also thought that CSCs drive the metastatic spread of cancer. The CSC compartment features a specific and phenotypically ...