A Modeling Framework For Immune-related Diseases

F. Castiglione; S. Motta; F. Pappalardo; M. Pennisi

Mathematical Modelling of Natural Phenomena (2012)

  • Volume: 7, Issue: 3, page 40-48
  • ISSN: 0973-5348

Abstract

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About twenty five years ago the first discrete mathematical model of the immune system was proposed. It was very simple and stylized. Later, many other computational models have been proposed each one adding a certain level of sophistication and detail to the description of the system. One of these, the Celada-Seiden model published back in 1992, was already mature at its birth, setting apart from the topic-specific nature of the other models. This one was not just a model but rather a framework with which one could implement his own immunological theories. Here we describe this computational framework, developed to perform simulations of different pathologies that are directly or indirectly connected to the immune system. We briefly describe the system first, then we report on few applications so to give the reader a clear idea of its practical utility in clinical research problems.

How to cite

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Castiglione, F., et al. "A Modeling Framework For Immune-related Diseases." Mathematical Modelling of Natural Phenomena 7.3 (2012): 40-48. <http://eudml.org/doc/222448>.

@article{Castiglione2012,
abstract = {About twenty five years ago the first discrete mathematical model of the immune system was proposed. It was very simple and stylized. Later, many other computational models have been proposed each one adding a certain level of sophistication and detail to the description of the system. One of these, the Celada-Seiden model published back in 1992, was already mature at its birth, setting apart from the topic-specific nature of the other models. This one was not just a model but rather a framework with which one could implement his own immunological theories. Here we describe this computational framework, developed to perform simulations of different pathologies that are directly or indirectly connected to the immune system. We briefly describe the system first, then we report on few applications so to give the reader a clear idea of its practical utility in clinical research problems.},
author = {Castiglione, F., Motta, S., Pappalardo, F., Pennisi, M.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {computational biology; CS-model; immunology; agent-based modeling},
language = {eng},
month = {6},
number = {3},
pages = {40-48},
publisher = {EDP Sciences},
title = {A Modeling Framework For Immune-related Diseases},
url = {http://eudml.org/doc/222448},
volume = {7},
year = {2012},
}

TY - JOUR
AU - Castiglione, F.
AU - Motta, S.
AU - Pappalardo, F.
AU - Pennisi, M.
TI - A Modeling Framework For Immune-related Diseases
JO - Mathematical Modelling of Natural Phenomena
DA - 2012/6//
PB - EDP Sciences
VL - 7
IS - 3
SP - 40
EP - 48
AB - About twenty five years ago the first discrete mathematical model of the immune system was proposed. It was very simple and stylized. Later, many other computational models have been proposed each one adding a certain level of sophistication and detail to the description of the system. One of these, the Celada-Seiden model published back in 1992, was already mature at its birth, setting apart from the topic-specific nature of the other models. This one was not just a model but rather a framework with which one could implement his own immunological theories. Here we describe this computational framework, developed to perform simulations of different pathologies that are directly or indirectly connected to the immune system. We briefly describe the system first, then we report on few applications so to give the reader a clear idea of its practical utility in clinical research problems.
LA - eng
KW - computational biology; CS-model; immunology; agent-based modeling
UR - http://eudml.org/doc/222448
ER -

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