An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map

Michael Poteat, and Jing He. "An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map." Molecular Based Mathematical Biology 5.1 (2017): 31-39. <http://eudml.org/doc/288130>.

@article{MichaelPoteat2017,
abstract = {Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.},
author = {Michael Poteat, Jing He},
journal = {Molecular Based Mathematical Biology},
language = {eng},
number = {1},
pages = {31-39},
title = {An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map},
url = {http://eudml.org/doc/288130},
volume = {5},
year = {2017},
}

TY - JOUR
AU - Michael Poteat
AU - Jing He
TI - An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map
JO - Molecular Based Mathematical Biology
PY - 2017
VL - 5
IS - 1
SP - 31
EP - 39
AB - Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.
LA - eng
UR - http://eudml.org/doc/288130
ER -