# An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map

Molecular Based Mathematical Biology (2017)

- Volume: 5, Issue: 1, page 31-39
- ISSN: 2299-3266

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topMichael Poteat, and Jing He. "An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map." Molecular Based Mathematical Biology 5.1 (2017): 31-39. <http://eudml.org/doc/288130>.

@article{MichaelPoteat2017,

abstract = {Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.},

author = {Michael Poteat, Jing He},

journal = {Molecular Based Mathematical Biology},

language = {eng},

number = {1},

pages = {31-39},

title = {An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map},

url = {http://eudml.org/doc/288130},

volume = {5},

year = {2017},

}

TY - JOUR

AU - Michael Poteat

AU - Jing He

TI - An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map

JO - Molecular Based Mathematical Biology

PY - 2017

VL - 5

IS - 1

SP - 31

EP - 39

AB - Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.

LA - eng

UR - http://eudml.org/doc/288130

ER -

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