Meccamsmi cellulari della immunodepressione da tumore

Paolo Mocarelli; Maria Luisa Villa; Augusto Pessina; Giuseppe Bigi; Enrico Clerici

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti (1970)

  • Volume: 49, Issue: 6, page 446-451
  • ISSN: 0392-7881

Abstract

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Adult mice grafted i.p. with Ehrlich ascites-carcinoma cells and then exposed to sublethal X—irradiation developed a significantly smaller number of "endogenous" spleen colonies than X-irradiated controls not grafted with tumor cells. Similar results were obtained when bone marrow cells from tumor bearing mice were injected i.v. into lethally X-irradiated mice, so as to produce "exogenous" spleen colonies. In both experiments, the Ehrlich ascites-carcinoma inoculum necessary to reduce significantly the frequency of hemopoietic stem cells was found equal to 8,5x105 cells. This is the number of tumor cells which inhibits the immune reactivity of host mice [1]. These findings are consistent with our working hypothesis that the immunological hyporeactivity of tumor-bearing animals is mediated through a functional defect of primitive bone marrow cells. Such a mechanism of action, similar to that recently proposed by Bennet and Steeves [14] for Friend leukemia virus and by Rowland and Hurd [15] for a chemical carcinogen (dimethylbenzanthracene), may point to a common pathway for the immunosuppression caused by malignant tumors.

How to cite

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Mocarelli, Paolo, et al. "Meccamsmi cellulari della immunodepressione da tumore." Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti 49.6 (1970): 446-451. <http://eudml.org/doc/296048>.

@article{Mocarelli1970,
author = {Mocarelli, Paolo, Villa, Maria Luisa, Pessina, Augusto, Bigi, Giuseppe, Clerici, Enrico},
journal = {Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti},
language = {ita},
month = {12},
number = {6},
pages = {446-451},
publisher = {Accademia Nazionale dei Lincei},
title = {Meccamsmi cellulari della immunodepressione da tumore},
url = {http://eudml.org/doc/296048},
volume = {49},
year = {1970},
}

TY - JOUR
AU - Mocarelli, Paolo
AU - Villa, Maria Luisa
AU - Pessina, Augusto
AU - Bigi, Giuseppe
AU - Clerici, Enrico
TI - Meccamsmi cellulari della immunodepressione da tumore
JO - Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti
DA - 1970/12//
PB - Accademia Nazionale dei Lincei
VL - 49
IS - 6
SP - 446
EP - 451
LA - ita
UR - http://eudml.org/doc/296048
ER -

References

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