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Let $L\left(H\right)$ denote the algebra of all bounded linear operators on a complex infinite dimensional Hilbert space $H$. For $A,B\in L\left(H\right)$, the generalized derivation ${\delta }_{A,B}$ and the multiplication operator $M_{A,B}$ are defined on $L\left(H\right)$ by ${\delta }_{A,B}\left(X\right)=AX-XB$ and $M_{A,B}\left(X\right)=AXB$. In this paper, we give a characterization of bounded operators $A$ and $B$ such that the range of $M_{A,B}$ is closed. We present some sufficient conditions for ${\delta }_{A,B}$ to have closed range. Some related results are also given.