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This paper deals with the existence of positive $\omega$-periodic solutions for the neutral functional differential equation with multiple delays $${(u\left(t\right)-cu(t-\delta ))}^{\text{'}}+a\left(t\right)u\left(t\right)=f(t,u(t-{\tau }_1),\cdots ,u(t-{\tau }_n)).$$ The essential inequality conditions on the existence of positive periodic solutions are obtained. These inequality conditions concern with the relations of $c$ and the coefficient function $a\left(t\right)$, and the nonlinearity $f(t,x_1,\cdots ,x_n)$. Our discussion is based on the perturbation method of positive operator and fixed point index theory in cones.