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The Effects of HIV-1 Infection on Latent Tuberculosis

Amy L. Bauer; Ian B. Hogue; Simeone Marino; Denise E. Kirschner — 2008

Mathematical Modelling of Natural Phenomena

Tuberculosis is the leading cause of death due to infectious diseases in the world today, and it is increasing due to co-infection with HIV-1, the causative agent of AIDS. Here, we examine the impact that HIV-1 infection has on persons with latent tuberculosis. Based on previous work, we develop a mathematical model of an adaptive immune response in the lung which considers relevant immune effectors such as macrophages, various sub-populations of T-cells, and key cytokines to predict which mechanisms...

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