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In vitro transmesothelial migration assays of ovarian cancer cells, isolated or
aggregated in multicellular spheroids, are reproduced deducing suitable Cellular Potts
Models (CPM). We show that the simulations are in good agreement with the experimental
evidence and that the overall process is regulated by the activity of matrix
metalloproteinases (MMPs) and by the interplay of the adhesive properties of the cells
with the extracellular matrix and...
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