Le potenzialità dei saggi sperimentali nella predizione dei rischi oncogeni ambientali. Un esempio: il cloruro di vinile
A wide project of correlated and integrated experiments, performed for testing the carcinogenic potentialities of vinyl chloride (VC) (a monomer of high industrial importance), is presented. The results showed that VC induces Zymbal's gland carcinomas, nephroblastomas, and hepatic and extra-hepatic angiosarcomas, in rats, and pulmonary tumours, mammary carcinomas and liver angiosarcomas, in mice. The experimental data have oriented the clinical observations and the epidemiological investigations,...