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In this paper we deal with the four-point singular boundary value problem $$\left\{\begin{array}{cc}{\left({\phi }_p\left(u^{\text{'}}\left(t\right)\right)\right)}^{\text{'}}+q\left(t\right)f(t,u\left(t\right),u^{\text{'}}\left(t\right))=0,\hfill & t\in (0,1),\hfill \\ u^{\text{'}}\left(0\right)-\alpha u\left(\xi \right)=0,u^{\text{'}}\left(1\right)+\beta u\left(\eta \right)=0,\hfill \end{array}\right.$$ where ${\phi }_p\left(s\right)={\left|s\right|}^{p-2}s$, $p>1$, $0<\xi <\eta <1$, $\alpha ,\beta >0$, $q\in C[0,1]$, $q\left(t\right)>0$, $t\in (0,1)$, and $f\in C\left(\right[0,1]\times (0,+\infty )\times ℝ,(0,+\infty \left)\right)$ may be singular at $u=0$. By using the well-known theory of the Leray-Schauder degree, sufficient conditions are given for the existence of positive solutions.