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By using Mawhin’s continuation theorem, we provide some sufficient conditions for the existence of solution for a class of high order differential equations of the form $$x^{\left(n\right)}=f(t,x,x^{\text{'}},\cdots ,x^{(n-1)}),t\in [0,1],$$ associated with the integral boundary conditions at resonance. The interesting point is that we shall deal with the case of nontrivial kernel of arbitrary dimension corresponding to high order differential operator which will cause some difficulties in constructing the generalized inverse operator.