Fast optical tracking of diffusion in time-dependent environment of brain extracellular space
An improved version of the Integrative Optical Imaging (IOI) method for diffusion measurements in a geometrically complex environment of the brain extracellular space has been developed. We present a theory for this Fast Optical Tracking Of Diffusion (FOTOD) which incorporates a time-dependent effective diffusion coefficient in homogeneous anisotropic media with time-dependent nonspecific linear clearance. FOTOD can be used to measure rapid changes in extracellular diffusion permeability that occur,...