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Cell Modelling of Hematopoiesis

N. BessonovL. Pujo-MenjouetV. Volpert — 2010

Mathematical Modelling of Natural Phenomena

In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow. ...

Diagnostics of the AML with immunophenotypical data

A. PlesaG. CiupercaV. LouvetL. Pujo-MenjouetS. GénieysC. DumontetX. ThomasV. Volpert — 2010

Mathematical Modelling of Natural Phenomena

Patients with acute myeloblastic leukemia (AML) are divided according to the French American British (FAB) classification into eight subgroups (M0 to M7) on the basis of their degree of maturation/differentiation. However, even if immunophenotypical characterization by flow cytometry is routinely used to distinguish between AML and acute lymphoblastic leukemia (ALL), it is not yet well established for the identification within the AML subgroups. Here we show that certain subgroups of AML can be...

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