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In this work, we introduce a new software created to study hematopoiesis at the cell
population level with the individually based approach. It can be used as an interface between theoretical
works on population dynamics and experimental observations. We show that this software
can be useful to study some features of normal hematopoiesis as well as some blood diseases such
as myelogenous leukemia. It is also possible to simulate cell communication and the formation of
cell colonies in the bone marrow.
...
Patients with acute myeloblastic leukemia (AML) are divided according to the French
American British (FAB) classification into eight subgroups (M0 to M7) on the basis of their degree
of maturation/differentiation. However, even if immunophenotypical characterization by flow cytometry
is routinely used to distinguish between AML and acute lymphoblastic leukemia (ALL), it
is not yet well established for the identification within the AML subgroups. Here we show that certain
subgroups of AML can be...
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