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The emergence of multidrug resistance among gram-negative bacilli is complex. Numerous
factors need to be considered, including the biological fitness cost of resistance, fitnesscompensatory
mutations and frequency and type of antibiotic exposure. A mathematical model
evaluating these complex relationships was developed in an individual colonized with strains of
pan-susceptible, single-, two- and multidrug-resistant (MDR) gram-negative bacilli (GN). The effect
of bacterial fitness, compensatory...
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