The search session has expired. Please query the service again.
The search session has expired. Please query the service again.
The search session has expired. Please query the service again.
The search session has expired. Please query the service again.
The invasive capability is fundamental in determining the malignancy of a solid tumor.
Revealing biomedical strategies that are able to partially decrease cancer invasiveness is
therefore an important approach in the treatment of the disease and has given rise to
multiple and models. We here develop
a hybrid computational framework, whose aim is to characterize the effects of the
different cellular and subcellular mechanisms involved in the invasion...
In vitro transmesothelial migration assays of ovarian cancer cells, isolated or
aggregated in multicellular spheroids, are reproduced deducing suitable Cellular Potts
Models (CPM). We show that the simulations are in good agreement with the experimental
evidence and that the overall process is regulated by the activity of matrix
metalloproteinases (MMPs) and by the interplay of the adhesive properties of the cells
with the extracellular matrix and...
Download Results (CSV)