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Given an integer $n\ge 3$, let $u_1,...,u_n$ be pairwise coprime integers $\ge 2$, $𝒟$ a family of nonempty proper subsets of $\{1,...,n\}$ with “enough” elements, and $\epsilon$ a function $𝒟\to \{\pm 1\}$. Does there exist at least one prime $q$ such that $q$ divides ${\prod }_{i\in I}{u}_i-\epsilon \left(I\right)$ for some $I\in 𝒟$, but it does not divide $u_1\cdots u_n$? We answer this question in the positive when the $u_i$ are prime powers and $\epsilon$ and $𝒟$ are subjected to certain restrictions. We use the result to prove that, if ${\epsilon }_0\in \{\pm 1\}$ and $A$ is a set of three or more primes that contains all prime divisors of any number of...