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In this work, we present necessary and sufficient conditions for oscillation of all solutions of a second-order functional differential equation of type $${\left(r\left(t\right){\left(z^{\text{'}}\left(t\right)\right)}^{\gamma }\right)}^{\text{'}}+\sum _{i=1}^m{q}_i\left(t\right)x^{{\alpha }_i}\left({\sigma }_i\left(t\right)\right)=0,t\ge t_0,$$ where $z\left(t\right)=x\left(t\right)+p\left(t\right)x\left(\tau \right(t\left)\right)$. Under the assumption ${\int }^{\infty }{\left(r\left(\eta \right)\right)}^{-1/\gamma }\mathrm{d}\eta =\infty$, we consider two cases when $\gamma >{\alpha }_i$ and $\gamma <{\alpha }_i$. Our main tool is Lebesgue’s dominated convergence theorem. Finally, we provide examples illustrating our results and state an open problem.