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Parameter estimation in non linear mixed effects models requires a large number of evaluations of the model to study. For ordinary differential equations, the overall computation time remains reasonable. However when the model itself is complex (for instance when it is a set of partial differential equations) it may be time consuming to evaluate it for a single set of parameters. The procedures of population parametrization (for instance using SAEM algorithms) are then very long and in some cases...
Patients with acute myeloblastic leukemia (AML) are divided according to the French
American British (FAB) classification into eight subgroups (M0 to M7) on the basis of their degree
of maturation/differentiation. However, even if immunophenotypical characterization by flow cytometry
is routinely used to distinguish between AML and acute lymphoblastic leukemia (ALL), it
is not yet well established for the identification within the AML subgroups. Here we show that certain
subgroups of AML can be...
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