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The effects of TAF on the development of the chick embryo are studied in vitro and in ovo. Treatments performed at early stages inhibit the histogenesis of the blood islets, and the embryonal development stops at stage 26/27 of Hamburger and Halmiton. These effects probably depend on the interference with the protein synthesis, both at level of mithocondria and of specific cytoplasmic proteins.
Glycerol formal, a fluid currently used as a drug solvent in toxicity testing has proved to be teratogenic when injected into pregnant rats. In chick embryos, employed in ovo at a final concentration of 0.001%, it induces more severe and generalized malformations (excephaly, anophtalmia or microphtalmia, coelosomia, ectopia viscerorum; beak and limbs are also frequently malformed and the heart is enlarged). Chick blastoderms developed in vitro (New's technique) and treated with the same substance...
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