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Suppose that ${\lambda }_1,{\lambda }_2,{\lambda }_3,{\lambda }_4$ are nonzero real numbers, not all negative, $\delta >0$, $𝒱$ is a well-spaced set, and the ratio ${\lambda }_1/{\lambda }_2$ is algebraic and irrational. Denote by $E(𝒱,N,\delta )$ the number of $v\in 𝒱$ with $v\le N$ such that the inequality $$|{\lambda }_1{p}_1^2+{\lambda }_2{p}_2^3+{\lambda }_3{p}_3^4+{\lambda }_4{p}_4^5-v|<v^{-\delta }$$ has no solution in primes $p_1$, $p_2$, $p_3$, $p_4$. We show that $$E(𝒱,N,\delta )\ll N^{1+2\delta -1/72+\epsilon }$$ for any $\epsilon >0$.