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Let $G$ be a simple connected graph with vertex set $V\left(G\right)=\{v_1,v_2,\cdots ,v_n\}$ and edge set $E\left(G\right)$, and let $d_{v_i}$ be the degree of the vertex $v_i$. Let $D\left(G\right)$ be the distance matrix and let $T_r\left(G\right)$ be the diagonal matrix of the vertex transmissions of $G$. The generalized distance matrix of $G$ is defined as $D_{\alpha }\left(G\right)=\alpha T_r\left(G\right)+(1-\alpha )D\left(G\right)$, where $0\le \alpha \le 1$. Let ${\lambda }_1\left(D_{\alpha }\left(G\right)\right)\ge {\lambda }_2\left(D_{\alpha }\left(G\right)\right)\ge ...\ge {\lambda }_n\left(D_{\alpha }\left(G\right)\right)$ be the generalized distance eigenvalues of $G$, and let $k$ be an integer with $1\le k\le n$. We denote by $S_k\left(D_{\alpha }\left(G\right)\right)={\lambda }_1\left(D_{\alpha }\left(G\right)\right)+{\lambda }_2\left(D_{\alpha }\left(G\right)\right)+...+{\lambda }_k\left(D_{\alpha }\left(G\right)\right)$ the sum of the $k$ largest generalized distance eigenvalues. The generalized distance spread of a graph $G$ is defined as $D_{\alpha }S\left(G\right)={\lambda }_1\left(D_{\alpha }\left(G\right)\right)-{\lambda }_n\left(D_{\alpha }\left(G\right)\right)$. We obtain some...