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On two methods for the parameter estimation problem with spatio-temporal FRAP data

Papáček, ŠtěpánJablonský, JiříMatonoha, Ctirad — 2015

Programs and Algorithms of Numerical Mathematics

FRAP (Fluorescence Recovery After Photobleaching) is a measurement technique for determination of the mobility of fluorescent molecules (presumably due to the diffusion process) within the living cells. While the experimental setup and protocol are usually fixed, the method used for the model parameter estimation, i.e. the data processing step, is not well established. In order to enhance the quantitative analysis of experimental (noisy) FRAP data, we firstly formulate the inverse problem of model...

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