Quantitative Analysis of Melanocyte Migration Based on Automated Cell Tracking under Phase Contrast Microscopy Considering the Combined Influence of Cell Division and Cell-Matrix Interactions
The aim of this study was to describe and analyze the regulation and spatio-temporal dynamics of melanocyte migration and its coupling to cell division and interaction with the matrix. The melanocyte lineage is particularly interesting because it is involved in both embryonic development and oncogenesis/metastasis (melanoma). Biological experiments were performed on two melanocyte cell lines established from wild-type and -catenin-transgenic mice ...