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We are concerned with the solvability of the fourth-order four-point boundary value problem ⎧ $u^{\left(4\right)}\left(t\right)=f(t,u\left(t\right),u^{\text{'}\text{'}}\left(t\right))$, t ∈ [0,1], ⎨ u(0) = u(1) = 0, ⎩ au”(ζ₁) - bu”’(ζ₁) = 0, cu”(ζ₂) + du”’(ζ₂) = 0, where 0 ≤ ζ₁ < ζ₂ ≤ 1, f ∈ C([0,1] × [0,∞) × (-∞,0],[0,∞)). By using Guo-Krasnosel’skiĭ’s fixed point theorem on cones, some criteria are established to ensure the existence, nonexistence and multiplicity of positive solutions for this problem.