Displaying similar documents to “Automated CFD Analysis for the Investigation of Flight Handling Qualities”

An empirical comparison of some experimental designs for the valuation of large variable annuity portfolios

Guojun Gan, Emiliano A. Valdez (2016)

Dependence Modeling

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Variable annuities contain complex guarantees, whose fair market value cannot be calculated in closed form. To value the guarantees, insurance companies rely heavily on Monte Carlo simulation, which is extremely computationally demanding for large portfolios of variable annuity policies. Metamodeling approaches have been proposed to address these computational issues. An important step of metamodeling approaches is the experimental design that selects a small number of representative...

A comparison between the continual reassessment method andD-optimum design for dose finding in phase I clinical trials

M. Iftakhar Alam (2016)

Biometrical Letters

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The continual reassessment method is a model-based procedure, described in the literature, used to determine the maximum tolerated dose in phase I clinical trials. The maximum tolerated dose can also be found under the framework of D-optimum design, where information is gathered in such a way so that asymptotic variability in the parameter estimates in minimised. This paper investigates the two methods under some realistic settings to explore any potential differences between them. Simulation...

Planning identification experiments for cell signaling pathways: An NFκB case study

Krzysztof Fujarewicz (2010)

International Journal of Applied Mathematics and Computer Science

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Mathematical modeling of cell signaling pathways has become a very important and challenging problem in recent years. The importance comes from possible applications of obtained models. It may help us to understand phenomena appearing in single cells and cell populations on a molecular level. Furthermore, it may help us with the discovery of new drug therapies. Mathematical models of cell signaling pathways take different forms. The most popular way of mathematical modeling is to use...

The comparison of three models applied to the analysis of a three-factor trial on hybrid maize (Zea maysL.) cultivars

Piotr Szulc, Iwona Mejza, Katarzyna Ambroży-Deręgowska, Kamila Nowosad, Jan Bocianowski (2016)

Biometrical Letters

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The aim of this paper is to present the comparison of three models applied to the analysis of a one-year study of protein yield for two types of hybrid maize cultivars under different forms of nitrogen fertilizer and doses of magnesium. The field trial was conducted in 2010 at the Agricultural Experimental Station in Swadzim (Poland). The results obtained were analyzed in terms of three randomization-derived models of observations. Consideration was given to three mixed systems, which...