HIV-1 integrase-DNA interactions investigated by molecular modelling.
Fenollar-Ferrer, C., Carnevale, V., Raugei, S., Carloni, P. (2008)
Computational & Mathematical Methods in Medicine
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Fenollar-Ferrer, C., Carnevale, V., Raugei, S., Carloni, P. (2008)
Computational & Mathematical Methods in Medicine
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Kheifetz, Yuri, Elishmereni, Moran, Horowitz, Smadar, Agur, Zvia (2006)
Computational & Mathematical Methods in Medicine
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Jarosław Śmieja (2010)
International Journal of Applied Mathematics and Computer Science
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The paper deals with the analysis of signaling pathways aimed at uncovering new regulatory processes regulating cell responses. First, general issues of comparing simulation and experimental data are discussed, and various aspects of data normalization are covered. Then, a model of a particular signaling pathway, induced by Interferon-β, is briefly introduced. It serves as an example illustrating how mathematical modeling can be used for inferring the structure of a regulatory system...
Krzysztof Arminski, Tomasz Zubowicz, Mietek A. Brdys (2013)
International Journal of Applied Mathematics and Computer Science
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Drinking Water Distribution Systems (DWDSs) play a key role in sustainable development of modern society. They are classified as critical infrastructure systems. This imposes a large set of highly demanding requirements on the DWDS operation and requires dedicated algorithms for on-line monitoring and control to tackle related problems. Requirements on DWDS availability restrict the usability of the real plant in the design phase. Thus, a proper model is crucial. Within this paper a...
de los Reyes V, Aurelio, Kappel, Franz (2010)
Mathematica Balkanica New Series
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AMS Subj. Classification: 92C30 In this study we investigated, modified and combined two existing mathematical cardiovascular models, a non-pulsatile global model and a simplified pulsatile left heart model. The first goal of the study was to integrate these models. The main objective is to have a global lumped parameter pulsatile model that predicts the pressures in the systemic and pulmonary circulation, and specifically the pulsatile pressures in the the finger arteries where...
Misra, Navodit, Lees, Daniel, Zhang, Tiequan, Schwartz, Russell (2008)
Computational & Mathematical Methods in Medicine
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Kovatchev, Boris P., Farhy, Leon S., Cox, Daniel J., Straume, Martin, Yankov, Vladimir I., Gonder-Frederick, Linda A., Clarke, William L. (1999)
Journal of Theoretical Medicine
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Milanov, Peter, Pencheva, Nevena (2011)
Serdica Journal of Computing
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The quantitative analysis of receptor-mediated effect is based on experimental concentration-response data in which the independent variable, the concentration of a receptor ligand, is linked with a dependent variable, the biological response. The steps between the drug–receptor interaction and the subsequent biological effect are to some extent unknown. The shape of the fitting curve of the experimental data may give some in-sights into the nature of the concentration–receptor–response...
Tomasz Barszcz, Piotr Czop (2011)
International Journal of Applied Mathematics and Computer Science
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The first-principle modeling of a feedwater heater operating in a coal-fired power unit is presented, along with a theoretical discussion concerning its structural simplifications, parameter estimation, and dynamical validation. The model is a part of the component library of modeling environments, called the Virtual Power Plant (VPP). The main purpose of the VPP is simulation of power generation installations intended for early warning diagnostic applications. The model was developed...
Do Hoai, Nam, Udo, Keiko, Mano, Akira (2011)
Journal of Applied Mathematics
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Kai-Uwe Dettmann, Dirk Söffker (2011)
International Journal of Applied Mathematics and Computer Science
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Modeling of reliability characteristics typically assumes that components and systems fail if a certain individual damage level is exceeded. Every (mechanical) system damage increases irreversibly due to employed loading and (mechanical) stress, respectively. The main issue of damage estimation is adequate determination of the actual state-of-damage. Several mathematical modeling approaches are known in the literature, focusing on the task of how loading effects damage progression (e.g.,...