Displaying similar documents to “Genetic Algorithms and Smoothing Filters in Solving the Geophysical Inversion Problem”

Segmentation of breast cancer fine needle biopsy cytological images

Maciej Hrebień, Piotr Steć, Tomasz Nieczkowski, Andrzej Obuchowicz (2008)

International Journal of Applied Mathematics and Computer Science


This paper describes three cytological image segmentation methods. The analysis includes the watershed algorithm, active contouring and a cellular automata GrowCut method. One can also find here a description of image pre-processing, Hough transform based pre-segmentation and an automatic nuclei localization mechanism used in our approach. Preliminary experimental results collected on a benchmark database present the quality of the methods in the analyzed issue. The discussion of common...

4D Embryogenesis image analysis using PDE methods of image processing

Paul Bourgine, Róbert Čunderlík, Olga Drblíková-Stašová, Karol Mikula, Mariana Remešíková, Nadine Peyriéras, Barbara Rizzi, Alessandro Sarti (2010)



In this paper, we introduce a set of methods for processing and analyzing long time series of 3D images representing embryo evolution. The images are obtained by in vivo scanning using a confocal microscope where one of the channels represents the cell nuclei and the other one the cell membranes. Our image processing chain consists of three steps: image filtering, object counting (center detection) and segmentation. The corresponding methods are based on numerical solution of nonlinear...

Optimisation of time-scheduled regimen for anti-cancer drug infusion

Claude Basdevant, Jean Clairambault, Francis Lévi (2005)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique


The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control...