Displaying similar documents to “Comparison of six models of antiangiogenic therapy”

An optimal control approach to cancer treatment under immunological activity

Urszula Ledzewicz, Mohammad Naghnaeian, Heinz Schättler (2011)

Applicationes Mathematicae

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Mathematical models for cancer treatment that include immunological activity are considered as an optimal control problem with an objective that is motivated by a separatrix of the uncontrolled system. For various growth models on the cancer cells the existence and optimality of singular controls is investigated. For a Gompertzian growth function a synthesis of controls that move the state into the region of attraction of a benign equilibrium point is developed.

Past, Present and Future of Brain Stimulation

J. Modolo, R. Edwards, J. Campagnaud, B. Bhattacharya, A. Beuter (2010)

Mathematical Modelling of Natural Phenomena

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Recent technological advances including brain imaging (higher resolution in space and time), miniaturization of integrated circuits (nanotechnologies), and acceleration of computation speed (Moore’s Law), combined with interpenetration between neuroscience, mathematics, and physics have led to the development of more biologically plausible computational models and novel therapeutic strategies. Today, mathematical models of irreversible...

Optimal solutions for a model of tumor anti-angiogenesis with a penalty on the cost of treatment

Urszula Ledzewicz, Vignon Oussa, Heinz Schättler (2009)

Applicationes Mathematicae

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The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given...

Optimal Control of a Cancer Cell Model with Delay

C. Collins, K.R. Fister, M. Williams (2010)

Mathematical Modelling of Natural Phenomena

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In this paper, we look at a model depicting the relationship of cancer cells in different development stages with immune cells and a cell cycle specific chemotherapy drug. The model includes a constant delay in the mitotic phase. By applying optimal control theory, we seek to minimize the cost associated with the chemotherapy drug and to minimize the number of tumor cells. Global existence of a solution has been shown for this model and ...

Optimal control for a class of compartmental models in cancer chemotherapy

Andrzej Świerniak, Urszula Ledzewicz, Heinz Schättler (2003)

International Journal of Applied Mathematics and Computer Science

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We consider a general class of mathematical models P for cancer chemotherapy described as optimal control problems over a fixed horizon with dynamics given by a bilinear system and an objective which is linear in the control. Several two- and three-compartment models considered earlier fall into this class. While a killing agent which is active during cell division constitutes the only control considered in the two-compartment model, Model A, also two three-compartment models, Models...

Modeling nonlinear road traffic networks for junction control

Tamás Péter (2012)

International Journal of Applied Mathematics and Computer Science

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The paper introduces a method of mathematical modeling of high scale road traffic networks, where a new special hypermatrix structure is intended to be used. The structure describes the inner-inner, inner-outer and outer-outer relations, and laws of a network area. The research examines the nonlinear equation system. The analysed model can be applied to the testing and planning of large-scale road traffic networks and the regulation of traffic systems. The elaborated model is in state...