Alessandro Bertoluzza,
Concezio Fagnano,
Maria Antonietta Morelli,
Raffaella Tosi
(1976)
Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti
Infrared and Raman spectra of aspirin and KH diaspirinate are reported and discussed in relation to the strong hydrogen bonds shown by these compounds, according to X-ray and neutronic diffraction data of the literature. This discussion is at the basis of a hypothesis put forth here on the probable inhibition mechanism of prostaglandin biosynthesis by aspirin-like drugs. The hypothesis considers the formation of strong hydrogen bonds between the acid function aspirin-like drugs and the...