Displaying similar documents to “Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement”

Regulatory network of drug-induced enzyme production: parameter estimation based on the periodic dosing response measurement

Papáček, Štěpán, Lynnyk, Volodymyr, Rehák, Branislav

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The common goal of systems pharmacology, i.e. systems biology applied to the field of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens . (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an...

Existence and uniqueness of positive periodic solutions of delayed Nicholson's blowflies models

Fei Long, Bingwen Liu (2012)

Annales Polonici Mathematici

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This paper is concerned with a class of Nicholson's blowflies models with multiple time-varying delays. By applying the coincidence degree, some criteria are established for the existence and uniqueness of positive periodic solutions of the model. Moreover, a totally new approach to proving the uniqueness of positive periodic solutions is proposed. In particular, an example is employed to illustrate the main results.

Periodic systems largely system equivalent to periodic discrete-time processes

Osvaldo Maria Grasselli, Sauro Longhi, Antonio Tornambè (2001)

Kybernetika

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In this paper, the problem of obtaining a periodic model in state-space form of a linear process that can be modeled by linear difference equations with periodic coefficients is considered. Such a problem was already studied and solved in [r71] on the basis of the notion of system equivalence, but under the assumption that the process has no null characteristic multiplier. In this paper such an assumption is removed in order to generalize the results in [r71] to linear periodic processes...

Continuous dependence on parameters and boundedness of solutions to a hysteresis system

Alexander M. Kamachkin, Dmitriy K. Potapov, Victoria V. Yevstafyeva (2022)

Applications of Mathematics

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We analyze an ordinary differential system with a hysteresis-relay nonlinearity in two cases when the system is autonomous or nonautonomous. Sufficient conditions for both the continuous dependence on the system parameters and the boundedness of the solutions to the system are obtained. We give a supporting example for the autonomous system.

The impact of uncertain parameters on ratchetting trends in hypoplasticity

Chleboun, Jan, Runcziková, Judita, Krejčí, Pavel

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Perturbed parameters are considered in a hypoplastic model of granular materials. For fixed parameters, the model response to a periodic stress loading and unloading converges to a limit state of strain. The focus of this contribution is the assessment of the change in the limit strain caused by varying model parameters.

Identification of parametric models with a priori knowledge of process properties

Krzysztof B. Janiszowski, Paweł Wnuk (2016)

International Journal of Applied Mathematics and Computer Science

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An approach to estimation of a parametric discrete-time model of a process in the case of some a priori knowledge of the investigated process properties is presented. The knowledge of plant properties is introduced in the form of linear bounds, which can be determined for the coefficient vector of the parametric model studied. The approach yields special biased estimation of model coefficients that preserves demanded properties. A formula for estimation of the model coefficients is derived...

Set-membership identifiability of nonlinear models and related parameter estimation properties

Carine Jauberthie, Louise Travé-Massuyès, Nathalie Verdière (2016)

International Journal of Applied Mathematics and Computer Science

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Identifiability guarantees that the mathematical model of a dynamic system is well defined in the sense that it maps unambiguously its parameters to the output trajectories. This paper casts identifiability in a set-membership (SM) framework and relates recently introduced properties, namely, SM-identifiability, μ-SM-identifiability, and ε-SM-identifiability, to the properties of parameter estimation problems. Soundness and ε-consistency are proposed to characterize these problems and...

Periodic solutions of nonlinear differential systems by the method of averaging

Zhanyong Li, Qihuai Liu, Kelei Zhang (2020)

Applications of Mathematics

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In many engineering problems, when studying the existence of periodic solutions to a nonlinear system with a small parameter via the local averaging theorem, it is necessary to verify some properties of the fundamental solution matrix to the corresponding linearized system along the periodic solution of the unperturbed system. But sometimes, it is difficult or it requires a lot of calculations. In this paper, a few simple and effective methods are introduced to investigate the existence...

Global Existence of Periodic Solutions in a Delayed Tumor-Immune Model

A. Kaddar, H. Talibi Alaoui (2010)

Mathematical Modelling of Natural Phenomena

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This paper is devoted to the study of global existence of periodic solutions of a delayed tumor-immune competition model. Also some numerical simulations are given to illustrate the theoretical results