From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology

E. Domingo; C. Perales

Mathematical Modelling of Natural Phenomena (2012)

  • Volume: 7, Issue: 5, page 105-122
  • ISSN: 0973-5348

Abstract

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RNA viruses replicate as complex and dynamic mutant distributions. They are termed viral quasispecies, in recognition of the fundamental contribution of quasispecies theory in our understanding of error-prone replicative entities. Viral quasispecies have launched a fertile field of transdiciplinary research, both experimental and theoretical. Here we review the origin and some implications of the quasispecies concept, with emphasis on internal interactions among components of the same mutant virus ensemble, a critical fact to design new antiviral strategies. We make the distinction between “intrinsic” and “extrinsic” properties of mutant distributions, and emphasize that there are several levels of complexity that can influence viral quasispecies behavior.

How to cite

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Domingo, E., and Perales, C.. "From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology." Mathematical Modelling of Natural Phenomena 7.5 (2012): 105-122. <http://eudml.org/doc/222404>.

@article{Domingo2012,
abstract = {RNA viruses replicate as complex and dynamic mutant distributions. They are termed viral quasispecies, in recognition of the fundamental contribution of quasispecies theory in our understanding of error-prone replicative entities. Viral quasispecies have launched a fertile field of transdiciplinary research, both experimental and theoretical. Here we review the origin and some implications of the quasispecies concept, with emphasis on internal interactions among components of the same mutant virus ensemble, a critical fact to design new antiviral strategies. We make the distinction between “intrinsic” and “extrinsic” properties of mutant distributions, and emphasize that there are several levels of complexity that can influence viral quasispecies behavior.},
author = {Domingo, E., Perales, C.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {RNA viruses; viral quasispecies; mutation rate; viral fitness; lethal mutagenesis},
language = {eng},
month = {10},
number = {5},
pages = {105-122},
publisher = {EDP Sciences},
title = {From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology},
url = {http://eudml.org/doc/222404},
volume = {7},
year = {2012},
}

TY - JOUR
AU - Domingo, E.
AU - Perales, C.
TI - From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology
JO - Mathematical Modelling of Natural Phenomena
DA - 2012/10//
PB - EDP Sciences
VL - 7
IS - 5
SP - 105
EP - 122
AB - RNA viruses replicate as complex and dynamic mutant distributions. They are termed viral quasispecies, in recognition of the fundamental contribution of quasispecies theory in our understanding of error-prone replicative entities. Viral quasispecies have launched a fertile field of transdiciplinary research, both experimental and theoretical. Here we review the origin and some implications of the quasispecies concept, with emphasis on internal interactions among components of the same mutant virus ensemble, a critical fact to design new antiviral strategies. We make the distinction between “intrinsic” and “extrinsic” properties of mutant distributions, and emphasize that there are several levels of complexity that can influence viral quasispecies behavior.
LA - eng
KW - RNA viruses; viral quasispecies; mutation rate; viral fitness; lethal mutagenesis
UR - http://eudml.org/doc/222404
ER -

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