Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment

Tokarev, A. A., et al. "Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment." Mathematical Modelling of Natural Phenomena 1.2 (2010): 124-137. <http://eudml.org/doc/222406>.

@article{Tokarev2010,
abstract = { Spatial dynamics of fibrin clot formation in non-stirred system activated by glass surface was studied as a function of FIX activity. Haemophilia B plasma was obtained from untreated patients with different levels of FIX deficiency and from severe haemophilia B patient treated with FIX concentrate (Ahemphil B) during its clearance with half-life t1/2=12 hours. As reported previously (Ataullakhanov et al. Biochim Biophys Acta 1998; 1425: 453-468), clot growth in space showed two distinct phases: activation and propagation. The activation phase is characterized by the time required to start clot growth from the activator, while the characteristic parameter of the propagation phase is the clot elongation rate. This rate reaches steady state in approximately ten minutes after the beginning of growth. In haemophilia B plasma, clot formation is substantially impaired: clot starts to grow from the activating surface later than in healthy donor plasma, and its propagation rate is considerably lower. The most significant abnormalities in clot growth kinetics are observed at FIX activity below 10% of normal. Simulation of these experiments was performed theoretically using a detailed biochemical model (Panteleev et al. Biophys J 2006; 90: 1489-1500) adapted for experimental conditions used. Suitability of the assumptions used to describe triggering contact activation was verified. },
author = {Tokarev, A. A., Krasotkina, Yu. V., Ovanesov, M. V., Panteleev, M. A., Azhigirova, M. A., Volpert, V. A., Ataullakhanov, F. I., Butilin, A. A.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {blood coagulation; intrinsic pathway; haemophilia B; factor IX concentrate; mathematical modelling; autowave process; mathematical modelling},
language = {eng},
month = {3},
number = {2},
pages = {124-137},
publisher = {EDP Sciences},
title = {Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment},
url = {http://eudml.org/doc/222406},
volume = {1},
year = {2010},
}

TY - JOUR
AU - Tokarev, A. A.
AU - Krasotkina, Yu. V.
AU - Ovanesov, M. V.
AU - Panteleev, M. A.
AU - Azhigirova, M. A.
AU - Volpert, V. A.
AU - Ataullakhanov, F. I.
AU - Butilin, A. A.
TI - Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment
JO - Mathematical Modelling of Natural Phenomena
DA - 2010/3//
PB - EDP Sciences
VL - 1
IS - 2
SP - 124
EP - 137
AB - Spatial dynamics of fibrin clot formation in non-stirred system activated by glass surface was studied as a function of FIX activity. Haemophilia B plasma was obtained from untreated patients with different levels of FIX deficiency and from severe haemophilia B patient treated with FIX concentrate (Ahemphil B) during its clearance with half-life t1/2=12 hours. As reported previously (Ataullakhanov et al. Biochim Biophys Acta 1998; 1425: 453-468), clot growth in space showed two distinct phases: activation and propagation. The activation phase is characterized by the time required to start clot growth from the activator, while the characteristic parameter of the propagation phase is the clot elongation rate. This rate reaches steady state in approximately ten minutes after the beginning of growth. In haemophilia B plasma, clot formation is substantially impaired: clot starts to grow from the activating surface later than in healthy donor plasma, and its propagation rate is considerably lower. The most significant abnormalities in clot growth kinetics are observed at FIX activity below 10% of normal. Simulation of these experiments was performed theoretically using a detailed biochemical model (Panteleev et al. Biophys J 2006; 90: 1489-1500) adapted for experimental conditions used. Suitability of the assumptions used to describe triggering contact activation was verified.
LA - eng
KW - blood coagulation; intrinsic pathway; haemophilia B; factor IX concentrate; mathematical modelling; autowave process; mathematical modelling
UR - http://eudml.org/doc/222406
ER -