A topological model of site-specific recombination that predicts the knot and link type of DNA products

Karin Valencia

Banach Center Publications (2014)

  • Volume: 100, Issue: 1, page 223-233
  • ISSN: 0137-6934

Abstract

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This is a short summary of a topological model of site-specific recombination, a cellular reaction that creates knots and links out of circular double stranded DNA molecules. The model is used to predict and characterise the topology of the products of a reaction on double stranded DNA twist knots. It is shown that all such products fall into a small family of Montesinos knots and links, meaning that the knot and link type of possible products is significantly reduced, thus aiding their experimental identification. We also mention direct applications of the model.

How to cite

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Karin Valencia. "A topological model of site-specific recombination that predicts the knot and link type of DNA products." Banach Center Publications 100.1 (2014): 223-233. <http://eudml.org/doc/282165>.

@article{KarinValencia2014,
abstract = {This is a short summary of a topological model of site-specific recombination, a cellular reaction that creates knots and links out of circular double stranded DNA molecules. The model is used to predict and characterise the topology of the products of a reaction on double stranded DNA twist knots. It is shown that all such products fall into a small family of Montesinos knots and links, meaning that the knot and link type of possible products is significantly reduced, thus aiding their experimental identification. We also mention direct applications of the model.},
author = {Karin Valencia},
journal = {Banach Center Publications},
keywords = {site-specific recombination; site-specific recombinases; tertiary structure of DNA; circular DNA; DNA supercoiling; DNA knots and links; substrate molecule; twist knots; product molecule; Montesinos knots and links; specific sites contain the recognition sequences and the cross-over sites; recombinase complex; synaptic complex; productive synapse; processive recombination; distributive recombination; serine and tyrosine recombinases},
language = {eng},
number = {1},
pages = {223-233},
title = {A topological model of site-specific recombination that predicts the knot and link type of DNA products},
url = {http://eudml.org/doc/282165},
volume = {100},
year = {2014},
}

TY - JOUR
AU - Karin Valencia
TI - A topological model of site-specific recombination that predicts the knot and link type of DNA products
JO - Banach Center Publications
PY - 2014
VL - 100
IS - 1
SP - 223
EP - 233
AB - This is a short summary of a topological model of site-specific recombination, a cellular reaction that creates knots and links out of circular double stranded DNA molecules. The model is used to predict and characterise the topology of the products of a reaction on double stranded DNA twist knots. It is shown that all such products fall into a small family of Montesinos knots and links, meaning that the knot and link type of possible products is significantly reduced, thus aiding their experimental identification. We also mention direct applications of the model.
LA - eng
KW - site-specific recombination; site-specific recombinases; tertiary structure of DNA; circular DNA; DNA supercoiling; DNA knots and links; substrate molecule; twist knots; product molecule; Montesinos knots and links; specific sites contain the recognition sequences and the cross-over sites; recombinase complex; synaptic complex; productive synapse; processive recombination; distributive recombination; serine and tyrosine recombinases
UR - http://eudml.org/doc/282165
ER -

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