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A topological model of site-specific recombination that predicts the knot and link type of DNA products

Karin Valencia — 2014

Banach Center Publications

This is a short summary of a topological model of site-specific recombination, a cellular reaction that creates knots and links out of circular double stranded DNA molecules. The model is used to predict and characterise the topology of the products of a reaction on double stranded DNA twist knots. It is shown that all such products fall into a small family of Montesinos knots and links, meaning that the knot and link type of possible products is significantly reduced, thus aiding their experimental...

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