Meccamsmi cellulari della immunodepressione da tumore
Adult mice grafted i.p. with Ehrlich ascites-carcinoma cells and then exposed to sublethal X—irradiation developed a significantly smaller number of "endogenous" spleen colonies than X-irradiated controls not grafted with tumor cells. Similar results were obtained when bone marrow cells from tumor bearing mice were injected i.v. into lethally X-irradiated mice, so as to produce "exogenous" spleen colonies. In both experiments, the Ehrlich ascites-carcinoma inoculum necessary to reduce significantly...