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About twenty five years ago the first discrete mathematical model of the immune system
was proposed. It was very simple and stylized. Later, many other computational models have
been proposed each one adding a certain level of sophistication and detail to the
description of the system. One of these, the Celada-Seiden model published back in 1992,
was already mature at its birth, setting apart from the topic-specific nature of the other
models. This...
The immune system is able to protect the host from tumor onset, and immune deficiencies
are accompanied by an increased risk of cancer. Immunology is one of the fields in biology
where the role of computational and mathematical modeling and analysis were recognized the
earliest, beginning from 60s of the last century. We introduce the two most common methods
in simulating the competition among the immune system, cancers and tumor immunology
strategies:...
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