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In this paper, we obtain existence results of periodic solutions of hamiltonian systems in the Orlicz-Sobolev space $W^1{L}^{\Phi }\left([0,T]\right)$. We employ the direct method of calculus of variations and we consider  a potential  function $F$ satisfying the inequality $\left|\nabla F(t,x)\right|\le b_1\left(t\right){\Phi }_0^{\text{'}}\left(\right|x\left|\right)+b_2\left(t\right)$, with $b_1,b_2\in L^1$ and  certain $N$-functions ${\Phi }_0$.

We obtain, by means of Banach's Fixed Point Theorem, convergence for the Picard iterations associated to a general nonlinear system of measure differential equations. We study the existence of left-continuous solutions defined on maximal intervals and we establish some properties of these maximal solutions.