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The paper was motivated by Kovacs’ paper (1973), Isaacs’ paper (1980) and a recent paper, due to Brešar et al. (2018), concerning Skolem-Noether algebras. Let $K$ be a unital commutative ring, not necessarily a field. Given a unital $K$-algebra $S$, where $K$ is contained in the center of $S$, $n\in \mathbb{N}$, the goal of this paper is to study the question: when can a homomorphism $\phi :{\mathrm{M}}_n\left(K\right)\to {\mathrm{M}}_n\left(S\right)$ be extended to an inner automorphism of ${\mathrm{M}}_n\left(S\right)$? As an application of main results presented in the paper, it is proved that if $S$ is a semilocal...