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A Maturity-Structured Mathematical Model of Mutation, Acquisition in the Absence of Homeostatic Regulation

S. N. GentryR. AshkenaziT. L. Jackson — 2009

Mathematical Modelling of Natural Phenomena

Most mammalian tissues are organized into a hierarchical structure of stem, progenitor, and differentiated cells. Tumors exhibit similar hierarchy, even if it is abnormal in comparison with healthy tissue. In particular, it is believed that a small population of cancer stem cells drives tumorigenesis in certain malignancies. These cancer stem cells are derived from transformed stem cells or mutated progenitors that have acquired stem-cell qualities, specifically the ability to self-renew. Similar...

The Kato-type spectrum and local spectral theory

T. L. MillerV. G. MillerMichael M. Neumann — 2007

Czechoslovak Mathematical Journal

Let T ( X ) be a bounded operator on a complex Banach space X . If V is an open subset of the complex plane such that λ - T is of Kato-type for each λ V , then the induced mapping f ( z ) ( z - T ) f ( z ) has closed range in the Fréchet space of analytic X -valued functions on V . Since semi-Fredholm operators are of Kato-type, this generalizes a result of Eschmeier on Fredholm operators and leads to a sharper estimate of Nagy’s spectral residuum of T . Our proof is elementary; in particular, we avoid the sheaf model of Eschmeier and...

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