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A natural number $n$ is said to be a $(k,r)$-integer if $n=a^{k}b$, where $k>r>1$ and $b$ is not divisible by the $r$th power of any prime. We study the distribution of such $(k,r)$-integers in the Piatetski-Shapiro sequence $\left\{\lfloor n^c\rfloor \right\}$ with $c>1$. As a corollary, we also obtain similar results for semi-$r$-free integers.

Let $a$ and $b\in \mathbb{N}$. Denote by $R_{a,b}$ the set of all integers $n>1$ whose canonical prime representation $n=p_1^{{\alpha }_1}{p}_2^{{\alpha }_2}\cdots p_r^{{\alpha }_r}$ has all exponents ${\alpha }_i$ $(1\le i\le r)$ being a multiple of $a$ or belonging to the arithmetic progression $at+b$, $t\in {\mathbb{N}}_0:=\mathbb{N}\cup \left\{0\right\}$. All integers in $R_{a,b}$ are called generalized square-full integers. Using the exponent pair method, an upper bound for character sums over generalized square-full integers is derived. An application on the distribution of generalized square-full integers in an arithmetic progression is given.