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A bayesian framework for the ratio of two Poisson rates in the context of vaccine efficacy trials

Stéphane LaurentCatherine Legrand — 2012

ESAIM: Probability and Statistics

In many applications, we assume that two random observations and are generated according to independent Poisson distributions ( λ S ) x1d4ab;() and ( μ T ) x1d4ab;() and we are interested in performing statistical inference on the ratio  =  /  of the two incidence rates. In vaccine efficacy trials, and are typically the numbers of cases in the vaccine and the control groups respectively, is called the relative risk and the statistical model is called ‘partial immunity model’. In this paper we start by defining...

On the L p index of spin Dirac operators on conical manifolds

André LegrandSergiu Moroianu — 2006

Studia Mathematica

We compute the index of the Dirac operator on a spin Riemannian manifold with conical singularities, acting from L p ( Σ ) to L q ( Σ ¯ ) with p,q > 1. When 1 + n/p - n/q > 0 we obtain the usual Atiyah-Patodi-Singer formula, but with a spectral cut at (n+1)/2 - n/q instead of 0 in the definition of the eta invariant. In particular we reprove Chou’s formula for the L² index. For 1 + n/p - n/q ≤ 0 the index formula contains an extra term related to the Calderón projector.

Suites spectrales de Serre en homotopie

André DidierjeanAndré Legrand — 1984

Annales de l'institut Fourier

Beaucoup d’informations sur les groupes de cohomologie d’un espace sont obtenues à partir de la suite spectrale de Serre. Dans cet article on construit une suite spectrale de Serre dans le cas “non stable”. Cette suite spectrale “non stable” permet des calculs de groupes d’homotopie d’espaces fonctionnels.

A Bayesian framework for the ratio of two Poisson rates in the context of vaccine efficacy trials

Stéphane LaurentCatherine Legrand — 2012

ESAIM: Probability and Statistics

In many applications, we assume that two random observations and are generated according to independent Poisson distributions ( λ S ) and ( μ T ) and we are interested in performing statistical inference on the ratio  =  /  of the two incidence rates. In vaccine efficacy trials, and are typically the numbers of cases in the vaccine and the control groups respectively, is called the relative risk and the statistical...

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