Displaying similar documents to “A comparison between the continual reassessment method andD-optimum design for dose finding in phase I clinical trials”

The comparison of three models applied to the analysis of a three-factor trial on hybrid maize (Zea maysL.) cultivars

Piotr Szulc, Iwona Mejza, Katarzyna Ambroży-Deręgowska, Kamila Nowosad, Jan Bocianowski (2016)

Biometrical Letters

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The aim of this paper is to present the comparison of three models applied to the analysis of a one-year study of protein yield for two types of hybrid maize cultivars under different forms of nitrogen fertilizer and doses of magnesium. The field trial was conducted in 2010 at the Agricultural Experimental Station in Swadzim (Poland). The results obtained were analyzed in terms of three randomization-derived models of observations. Consideration was given to three mixed systems, which...

Planning identification experiments for cell signaling pathways: An NFκB case study

Krzysztof Fujarewicz (2010)

International Journal of Applied Mathematics and Computer Science

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Mathematical modeling of cell signaling pathways has become a very important and challenging problem in recent years. The importance comes from possible applications of obtained models. It may help us to understand phenomena appearing in single cells and cell populations on a molecular level. Furthermore, it may help us with the discovery of new drug therapies. Mathematical models of cell signaling pathways take different forms. The most popular way of mathematical modeling is to use...

Automated CFD Analysis for the Investigation of Flight Handling Qualities

M. Ghoreyshi, K. J. Badcock, A. Da Ronch, D. Vallespin, A. Rizzi (2011)

Mathematical Modelling of Natural Phenomena

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Physics based simulation is widely seen as a way of increasing the information about aircraft designs earlier in their definition, thus helping with the avoidance of unanticipated problems as the design is refined. This paper reports on an effort to assess the automated use of computational fluid dynamics level aerodynamics for the development of tables for flight dynamics analysis at the conceptual stage. These tables are then used to...

An empirical comparison of some experimental designs for the valuation of large variable annuity portfolios

Guojun Gan, Emiliano A. Valdez (2016)

Dependence Modeling

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Variable annuities contain complex guarantees, whose fair market value cannot be calculated in closed form. To value the guarantees, insurance companies rely heavily on Monte Carlo simulation, which is extremely computationally demanding for large portfolios of variable annuity policies. Metamodeling approaches have been proposed to address these computational issues. An important step of metamodeling approaches is the experimental design that selects a small number of representative...

Some applications of weighing designs

Małgorzata Graczyk (2013)

Biometrical Letters

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The purpose of this paper is to apply results on weighing designs to the setting of 2m factorial designs. Using weighing designs, we give some proposals for experimental plans. Relevant counterexamples are indicated. Also the results of a simulation study on the existence of weighing designs are presented.

Optimum chemical balance weighing designs under the restriction on weighings

Bronisław Ceranka, Małgorzata Graczyk (2001)

Discussiones Mathematicae Probability and Statistics

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The paper deals with the problem of estimating individual weights of objects, using a chemical balance weighing design under the restriction on the number in which each object is weighed. A lower bound for the variance of each of the estimated weights from this chemical balance weighing design is obtained and a necessary and sufficient condition for this lower bound to be attained is given. The incidence matrix of ternary balanced block design is used to construct optimum chemical balance...