Displaying similar documents to “On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy”

Identification of parametric models with a priori knowledge of process properties

Krzysztof B. Janiszowski, Paweł Wnuk (2016)

International Journal of Applied Mathematics and Computer Science

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An approach to estimation of a parametric discrete-time model of a process in the case of some a priori knowledge of the investigated process properties is presented. The knowledge of plant properties is introduced in the form of linear bounds, which can be determined for the coefficient vector of the parametric model studied. The approach yields special biased estimation of model coefficients that preserves demanded properties. A formula for estimation of the model coefficients is derived...

Numerical optimization of parameters in systems of differential equations

Martínek, Josef, Kučera, Václav

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We present results on the estimation of unknown parameters in systems of ordinary differential equations in order to fit the output of models to real data. The numerical method is based on the nonlinear least squares problem along with the solution of sensitivity equations corresponding to the differential equations. We will present the performance of the method on the problem of fitting the output of basic compartmental epidemic models to data from the Covid-19 epidemic. This allows...

Set-membership identifiability of nonlinear models and related parameter estimation properties

Carine Jauberthie, Louise Travé-Massuyès, Nathalie Verdière (2016)

International Journal of Applied Mathematics and Computer Science

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Identifiability guarantees that the mathematical model of a dynamic system is well defined in the sense that it maps unambiguously its parameters to the output trajectories. This paper casts identifiability in a set-membership (SM) framework and relates recently introduced properties, namely, SM-identifiability, μ-SM-identifiability, and ε-SM-identifiability, to the properties of parameter estimation problems. Soundness and ε-consistency are proposed to characterize these problems and...

Modeling the Dynamics of the Cardiovascular-respiratory System (CVRS) in Humans, a Survey

F. Kappel (2012)

Mathematical Modelling of Natural Phenomena

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In this paper we give a survey on modeling efforts concerning the CVRS. The material we discuss is organized in accordance with modeling goals and stresses control and transport issues. We also address basic modeling approaches and discuss some of the challenges for mathematical modeling methodologies in the context of parameter estimation and model validation.

Some Parameter Estimation Issues in Functional-Structural Plant Modelling

P.-H. Cournède, V. Letort, A. Mathieu, M. Z. Kang, S. Lemaire, S. Trevezas, F. Houllier, P. de Reffye (2011)

Mathematical Modelling of Natural Phenomena

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The development of functional-structural plant models has opened interesting perspectives for a better understanding of plant growth as well as for potential applications in breeding or decision aid in farm management. Parameterization of such models is however a difficult issue due to the complexity of the involved biological processes and the interactions between these processes. The estimation of parameters from experimental data by...

A Galerkin strategy with Proper Orthogonal Decomposition for parameter-dependent problems – Analysis, assessments and applications to parameter estimation

D. Chapelle, A. Gariah, P. Moireau, J. Sainte-Marie (2013)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

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We address the issue of parameter variations in POD approximations of time-dependent problems, without any specific restriction on the form of parameter dependence. Considering a parabolic model problem, we propose a POD construction strategy allowing us to obtain some error estimates controlled by the POD remainder – in the construction procedure – and some parameter-wise interpolation errors for the model solutions. We provide a thorough numerical assessment of this strategy with the...